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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
17/07/2023 |
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Data da última atualização: |
22/08/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 4 |
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Autoria: |
ROCHA, R. de F. B.; GARCIA, A. O.; OTTO, P. I.; SANTOS, M. G. dos; SILVA, M. V. G. B.; MARTINS, M. F.; MACHADO, M. A.; PANETTO, J. C. do C.; GUIMARÃES, S. E. F. |
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Afiliação: |
RENATA DE FÁTIMA BRETANHA ROCHA, Universidade Federal de Viçosa; ARIELLY OLIVEIRA GARCIA, Universidade Federal de Viçosa; PAMELA ITAJARA OTTO, Universidade Federal de Santa Maria; MATEUS GUIMARÃES DOS SANTOS, Universidade Federal de Viçosa; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; MARTA FONSECA MARTINS, CNPGL; MARCO ANTONIO MACHADO, CNPGL; JOAO CLAUDIO DO CARMO PANETTO, CNPGL; SIMONE ELIZA FACIONI GUIMARÃES, Universidade Federal de Viçosa. |
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Título: |
Single-step genome-wide association studies and post-GWAS analyses for the number of oocytes and embryos in Gir cattle. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Mammalian Genome, v. 34, p. 497-508, 2023. |
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DOI: |
https://doi.org/10.1007/s00335-023-10009-0 |
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Idioma: |
Inglês |
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Conteúdo: |
Genome-Wide Association Studies (GWAS) are used for identifcation of quantitate trait loci (QTL) and genes associated with several traits. We aimed to identify genomic regions, genes, and biological processes associated with number of total and viable oocytes, and number of embryos in Gir dairy cattle. A dataset with 17,526 follicular aspirations, including the following traits: number of viable oocytes (VO), number of total oocytes (TO), and number of embryos (EMBR) from 1641 Gir donors was provided by fve diferent stock farms. A genotype fle with 2093 animals and 395,524 SNP markers was used to perform a single-step GWAS analysis for each trait. The top 10 windows with the highest percentage of additive genetic variance explained by 100 adjacent SNPs were selected. The genomic regions identifed in our work were overlapped with QTLs from QTL database on chromosomes 1, 2, 5, 6, 7, 8, 9, 13, 17, 18, 20, 21, 22, 24, and 29. These QTLs were classifed as External, Health, Meat and carcass, Production or Reproduction traits, and about 38% were related to Reproduction. In total, 117 genes were identifed, of which 111 were protein-coding genes. Exclusively associations were observed for 42 genes with EMBR, and 1 with TO. Also, 42 genes were in common between VO and TO, 28 between VO and EMBR, and four genes were in common among all traits. In conclusion, great part of the identifed genes plays a functional role in initial embryo development or general cell functions. The protein-coding genes ARNT, EGR1, HIF1A, AHR, and PAX2 are good markers for the production of oocytes and embryos in Gir cattle. MenosGenome-Wide Association Studies (GWAS) are used for identifcation of quantitate trait loci (QTL) and genes associated with several traits. We aimed to identify genomic regions, genes, and biological processes associated with number of total and viable oocytes, and number of embryos in Gir dairy cattle. A dataset with 17,526 follicular aspirations, including the following traits: number of viable oocytes (VO), number of total oocytes (TO), and number of embryos (EMBR) from 1641 Gir donors was provided by fve diferent stock farms. A genotype fle with 2093 animals and 395,524 SNP markers was used to perform a single-step GWAS analysis for each trait. The top 10 windows with the highest percentage of additive genetic variance explained by 100 adjacent SNPs were selected. The genomic regions identifed in our work were overlapped with QTLs from QTL database on chromosomes 1, 2, 5, 6, 7, 8, 9, 13, 17, 18, 20, 21, 22, 24, and 29. These QTLs were classifed as External, Health, Meat and carcass, Production or Reproduction traits, and about 38% were related to Reproduction. In total, 117 genes were identifed, of which 111 were protein-coding genes. Exclusively associations were observed for 42 genes with EMBR, and 1 with TO. Also, 42 genes were in common between VO and TO, 28 between VO and EMBR, and four genes were in common among all traits. In conclusion, great part of the identifed genes plays a functional role in initial embryo development or general cell functions. The protein-co... Mostrar Tudo |
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Palavras-Chave: |
Associação genômica. |
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Thesagro: |
Bovino; Embrião Animal; Gado Gir; Genética Animal. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02508naa a2200289 a 4500
001 2154972
005 2023-08-22
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s00335-023-10009-0$2DOI
100 1 $aROCHA, R. de F. B.
245 $aSingle-step genome-wide association studies and post-GWAS analyses for the number of oocytes and embryos in Gir cattle.$h[electronic resource]
260 $c2023
520 $aGenome-Wide Association Studies (GWAS) are used for identifcation of quantitate trait loci (QTL) and genes associated with several traits. We aimed to identify genomic regions, genes, and biological processes associated with number of total and viable oocytes, and number of embryos in Gir dairy cattle. A dataset with 17,526 follicular aspirations, including the following traits: number of viable oocytes (VO), number of total oocytes (TO), and number of embryos (EMBR) from 1641 Gir donors was provided by fve diferent stock farms. A genotype fle with 2093 animals and 395,524 SNP markers was used to perform a single-step GWAS analysis for each trait. The top 10 windows with the highest percentage of additive genetic variance explained by 100 adjacent SNPs were selected. The genomic regions identifed in our work were overlapped with QTLs from QTL database on chromosomes 1, 2, 5, 6, 7, 8, 9, 13, 17, 18, 20, 21, 22, 24, and 29. These QTLs were classifed as External, Health, Meat and carcass, Production or Reproduction traits, and about 38% were related to Reproduction. In total, 117 genes were identifed, of which 111 were protein-coding genes. Exclusively associations were observed for 42 genes with EMBR, and 1 with TO. Also, 42 genes were in common between VO and TO, 28 between VO and EMBR, and four genes were in common among all traits. In conclusion, great part of the identifed genes plays a functional role in initial embryo development or general cell functions. The protein-coding genes ARNT, EGR1, HIF1A, AHR, and PAX2 are good markers for the production of oocytes and embryos in Gir cattle.
650 $aBovino
650 $aEmbrião Animal
650 $aGado Gir
650 $aGenética Animal
653 $aAssociação genômica
700 1 $aGARCIA, A. O.
700 1 $aOTTO, P. I.
700 1 $aSANTOS, M. G. dos
700 1 $aSILVA, M. V. G. B.
700 1 $aMARTINS, M. F.
700 1 $aMACHADO, M. A.
700 1 $aPANETTO, J. C. do C.
700 1 $aGUIMARÃES, S. E. F.
773 $tMammalian Genome$gv. 34, p. 497-508, 2023.
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